GTF2H4

GTF2H4, also known as TFIIH subunit 4, is a gene that encodes a protein involved in transcription. The protein is a component of the general transcription factor II H (TFIIH), a multi-subunit complex essential for initiating and processing RNA polymerase II transcription. TFIIH plays a critical role in both DNA repair pathways and the regulation of gene expression. The GTF2H4 gene is located on chromosome 16. Mutations in GTF2H4 have been associated with certain human diseases, although the specific clinical manifestations can vary. Research into the precise functions of the GTF2H4 protein and its contribution to the TFIIH complex is ongoing. The protein's interactions with other subunits within TFIIH are crucial for the complex's overall enzymatic activities, including helicase and kinase functions. These activities are vital for unwinding DNA during transcription initiation and for phosphorylating the C-terminal domain of RNA polymerase II, which is necessary for promoter clearance and elongation. Understanding the role of GTF2H4 contributes to a broader understanding of the fundamental mechanisms of gene expression and DNA repair.