Fosfotyrosine

Fosfotyrosine, also known as O-phosphotyrosine, is a post-translational modification of the amino acid tyrosine. It occurs when a phosphate group is added to the hydroxyl group of tyrosine, forming a phosphotyrosine residue. This modification is crucial in various biological processes, including signal transduction, cell growth, and differentiation. Fosfotyrosine is often involved in the regulation of protein-protein interactions and the activation of enzymes. It is a common target for protein kinases, which add the phosphate group, and protein phosphatases, which remove it. The presence of fosfotyrosine can be detected using various biochemical techniques, such as mass spectrometry and immunoblotting. Abnormal levels of fosfotyrosine have been linked to several diseases, including cancer and neurodegenerative disorders. Understanding the role of fosfotyrosine in these conditions is an active area of research.