Fibrinolytiques
Fibrinolytiques are a class of enzymes and medications that play a crucial role in breaking down fibrin, a protein involved in blood clotting. This process is known as fibrinolysis, a natural mechanism that prevents excessive clot formation and maintains vascular patency. Fibrinolytic agents are used therapeutically to dissolve abnormal blood clots, particularly in conditions such as deep vein thrombosis, pulmonary embolism, and acute myocardial infarction.
The primary endogenous fibrinolytic enzyme is plasmin, which is generated from its precursor, plasminogen, through the
Fibrinolytic therapy is essential in acute coronary syndromes, where rapid clot dissolution can restore blood flow
Common side effects include bleeding at injection sites, gastrointestinal bleeding, and intracranial hemorrhage in rare cases.
Resistance to fibrinolytic therapy can occur due to impaired plasminogen activation or elevated levels of fibrinolytic