FSHRgenen

The FSHR gene, also known as the follicle-stimulating hormone receptor gene, is located on chromosome 2p21. It encodes a protein that is a member of the G protein-coupled receptor superfamily. This receptor is primarily expressed in the granulosa cells of the ovary in females and the Sertoli cells of the testis in males. The protein product of the FSHR gene is essential for reproductive function. In females, FSHR plays a critical role in follicular development, ovulation, and the production of steroid hormones. Binding of follicle-stimulating hormone (FSH) to its receptor triggers intracellular signaling pathways that promote the growth and maturation of ovarian follicles. In males, FSHR is involved in spermatogenesis, the process of sperm production. FSH binding to FSHR in Sertoli cells supports the development and maintenance of sperm. Genetic variations within the FSHR gene have been associated with a range of reproductive conditions, including infertility, polycystic ovary syndrome (PCOS), and premature ovarian failure. Research continues to explore the functional significance of different FSHR gene polymorphisms and their impact on reproductive health.