FGFR1IIIb

FGFR1IIIb refers to a specific isoform of the Fibroblast Growth Factor Receptor 1 (FGFR1) gene. This receptor is a tyrosine kinase that plays a crucial role in cell growth, differentiation, and development. The FGFR1 gene can produce different protein isoforms through alternative splicing, and FGFR1IIIb is one such variant. Isoforms are different versions of a protein that arise from the same gene.

The FGFR1IIIb isoform is characterized by the presence of an alternative exon in its third immunoglobulin-like domain. This difference in splicing leads to variations in the receptor's extracellular domain, which can affect its binding affinity for specific fibroblast growth factors (FGFs) and its subsequent signaling capabilities. FGFR1IIIb is primarily expressed in epithelial cells and is known to be a key receptor for FGFs involved in epithelial development and tissue homeostasis. Dysregulation of FGFR1 signaling, including the expression of specific isoforms like FGFR1IIIb, has been implicated in various diseases, including certain types of cancer and developmental disorders. Research into the specific functions and implications of FGFR1IIIb is ongoing to understand its precise role in normal physiology and disease pathogenesis.