Deubiquitinaser
Deubiquitinases (DUBs) are enzymes that remove ubiquitin molecules from substrate proteins, counteracting ubiquitination by E3 ligases. By editing ubiquitin chains, they regulate protein stability, localization, and activity, influencing numerous cellular processes. DUBs function within the ubiquitin–proteasome system and help recycle ubiquitin.
DUBs are divided into several families. The largest group comprises cysteine proteases, including ubiquitin-specific proteases (USPs),
Mechanistically, DUBs employ an active-site cysteine (cysteine proteases) or a zinc-dependent catalytic center (JAMM/MPN+) to cleave
Biological roles are diverse, including regulation of protein turnover, DNA repair, transcription, signal transduction, endocytosis, and
Because of their central role, DUBs are attractive therapeutic targets. Inhibitors and modulators for several DUBs,