DNAtuloksiin
DNAtuloksiin (Finnish for DNA toxins) refers to substances that damage DNA and produce genotoxic effects in cells. They can be natural or synthetic, and may contribute to mutations, cancer, or cell death by interfering with replication or transcription.
DNAtuloksiin act by several mechanisms. DNA intercalation inserts between base pairs; alkylation adds reactive groups to
These toxins arise in nature from bacteria, fungi, plants, and marine organisms, as well as from synthetic
Applications and implications: In medicine, DNA-damaging agents form a cornerstone of cancer therapy, with toxicity managed
Detection and regulation: Genotoxicity is assessed by assays like the Ames test, comet assay, and γ-H2AX foci.