DNADamageResponse
DNADamageResponse is the set of cellular processes activated in response to DNA damage in order to preserve genome integrity. It encompasses damage sensing, signal transduction, and effector responses that coordinate cell cycle control, DNA repair, and, when necessary, programmed cell fate decisions.
Core components of the DNADamageResponse include sensor proteins that recognize lesions and recruit kinase signaling cascades.
The DNADamageResponse regulates cell cycle checkpoints, enabling time for repair before replication or division. It also
In research and medicine, the DNADamageResponse is studied to understand cancer, aging, and responses to genotoxic