DHHCmotif

DHHCmotif is a sequence motif found in proteins, specifically in the N-terminal region of the human dehydroascorbate reductase (DHAR) protein. This motif is characterized by the sequence "DHHC" and is crucial for the function of DHAR. DHAR is an enzyme that plays a significant role in the ascorbate-glutathione cycle, which is essential for maintaining redox homeostasis in cells. The DHHCmotif is believed to be involved in the binding of the enzyme to its substrate, dehydroascorbate, and in the regulation of its activity. Mutations in the DHHCmotif have been associated with various diseases, including neurodegeneration and cancer. The motif is also conserved across different species, suggesting its importance in the evolution of the ascorbate-glutathione cycle. Further research is needed to fully understand the role of the DHHCmotif in DHAR function and its implications in human health and disease.