CerS1

CerS1, also known as Ceramide Synthase 1, is an enzyme encoded by the CERES gene in humans. It is a key component of the sphingolipid metabolic pathway, specifically involved in the de novo synthesis of ceramides. Ceramides are essential lipids that play crucial roles in various cellular processes, including cell growth, differentiation, apoptosis, and signal transduction. CerS1 primarily catalyzes the transfer of a fatty acid to a sphingoid base, such as sphingosine, to form ceramide. The specific fatty acids that CerS1 incorporates can vary, influencing the diverse biological functions of the resulting ceramides. Research has indicated that CerS1 is involved in the synthesis of specific ceramide species, which are important for maintaining skin barrier function and regulating immune responses. Dysregulation of CerS1 activity has been implicated in various diseases, including certain types of cancer and inflammatory conditions. Understanding the function and regulation of CerS1 is therefore vital for unraveling the complex roles of sphingolipids in health and disease.