CbzCl

CbzCl, also known as benzyl chloroformate, is a chemical compound with the molecular formula C8H7ClO2. It is a colorless liquid with a pungent odor and is highly reactive. CbzCl is primarily used as a protecting group in organic synthesis, particularly for amines. The benzyl carbamate protecting group (Cbz group) is introduced by reacting an amine with CbzCl. This protecting group is stable under a variety of reaction conditions and can be removed later, typically by catalytic hydrogenation. This selective protection and deprotection strategy is crucial in the synthesis of complex organic molecules, including peptides and pharmaceuticals. CbzCl is also used in the synthesis of other organic compounds, such as isocyanates and carbonates. Due to its reactivity, CbzCl is considered a hazardous substance and should be handled with appropriate safety precautions, including working in a well-ventilated area and wearing protective gear. It can react vigorously with water and bases, producing toxic gases. Storage should be in a cool, dry place away from incompatible materials.