CTSE

CTSE, also known as Cathepsin E, is a lysosomal aspartic protease. It plays a role in the degradation of proteins within the cell's lysosomes. CTSE is primarily expressed in immune cells, particularly antigen-presenting cells like macrophages and dendritic cells, as well as in certain epithelial cells. Its enzymatic activity is crucial for processing antigens, which are then presented to T cells, thus contributing to the adaptive immune response. Beyond immunity, CTSE is implicated in other cellular processes, including cell growth and differentiation. Dysregulation of CTSE has been linked to various pathological conditions, such as autoimmune diseases and certain types of cancer, suggesting its involvement in disease pathogenesis. Research continues to explore the full spectrum of CTSE functions and its potential as a therapeutic target. The gene encoding CTSE is located on human chromosome 1q23.1. Its precise mechanisms of action and interactions with other cellular components are subjects of ongoing investigation.