CR3binding
CR3 binding refers to the interaction of the complement receptor 3 (CR3) with its ligands. CR3, also known as Mac-1 or integrin alphaM beta2, is a transmembrane protein found on the surface of various immune cells, particularly phagocytes like neutrophils and macrophages. It plays a crucial role in innate immunity, mediating cell adhesion, migration, and phagocytosis.
The primary ligands for CR3 are opsonized particles, such as bacteria and fungi coated with complement fragments,
Beyond complement fragments, CR3 can also bind to other molecules, including certain extracellular matrix proteins like