CD32c

CD32c is a protein also known as FcγRIIc. It belongs to the immunoglobulin receptor superfamily. This receptor is primarily found on the surface of certain immune cells, including B cells, monocytes, and macrophages. Its main function is to bind to the Fc region of antibodies, specifically IgG. This binding plays a crucial role in regulating immune responses. When CD32c binds to antibody-coated pathogens or cells, it can trigger a variety of downstream signaling events. These events can include the activation or inhibition of cellular functions depending on the specific immune cell and the context of the interaction. For instance, on B cells, CD32c can modulate B cell activation and antibody production. In macrophages and monocytes, CD32c engagement can contribute to phagocytosis and the release of inflammatory mediators. The specific signaling pathways activated by CD32c can be complex and are influenced by other co-receptors and cellular environments. Dysregulation of CD32c expression or function has been implicated in various autoimmune diseases and inflammatory conditions, suggesting its importance in maintaining immune homeostasis. Research continues to explore the precise mechanisms of CD32c signaling and its therapeutic potential.