CD211

CD211, also known as IL1RL1 or ST2, is a transmembrane receptor belonging to the interleukin-1 receptor family. It is expressed on a variety of cells, including lymphocytes, mast cells, and eosinophils. CD211 plays a significant role in immune responses, particularly in the context of allergic inflammation and T helper 2 (Th2) cell differentiation.

The primary ligand for CD211 is interleukin-33 (IL-33), a cytokine released from damaged or stressed cells. Upon binding to CD211, IL-33 triggers intracellular signaling pathways that lead to the activation of immune cells. This activation can promote the production of pro-inflammatory cytokines, enhance mast cell degranulation, and contribute to the development of Th2 immune responses.

CD211 has been implicated in various immunological and pathological processes. It is involved in conditions such as asthma, atopic dermatitis, and other allergic diseases. Research suggests that targeting the CD211/IL-33 axis may offer therapeutic potential for inflammatory and allergic disorders. Furthermore, CD211 expression is also found on some non-immune cells, and its role in other physiological processes is an ongoing area of investigation. The specific functions of CD211 can vary depending on the cell type and the biological context.