CD117n

CD117n, also known as KITLG or Stem Cell Factor Receptor Ligand, is the ligand for the c-Kit receptor tyrosine kinase. This receptor plays a crucial role in various cellular processes, including cell survival, proliferation, differentiation, and migration. CD117n itself is a soluble or membrane-bound protein that binds to the c-Kit receptor, initiating intracellular signaling cascades.

The CD117n protein is encoded by the KITLG gene and is expressed in a variety of cell types, including fibroblasts, endothelial cells, and some immune cells. Its primary function is to stimulate the growth and development of various cell populations. In particular, it is essential for the development of hematopoietic stem cells, melanocytes, germ cells, and interstitial cells of Cajal. Disruptions in the CD117n signaling pathway can have significant implications for human health.

Mutations or dysregulation of the CD117n-c-Kit axis are implicated in a range of diseases. For example, it plays a role in the development and progression of gastrointestinal stromal tumors (GISTs), where mutations in the c-Kit receptor lead to its constitutive activation. Furthermore, CD117n is involved in the pathogenesis of mastocytosis, a disorder characterized by the abnormal proliferation of mast cells. Research into CD117n and its interactions continues to provide insights into normal cellular development and the mechanisms underlying various diseases.