CASPR3

Caspr3 is a gene that encodes a protein belonging to the Caspr (Contactin-associated protein) family. These proteins are involved in cell adhesion and neuronal development. The Caspr3 protein is a transmembrane glycoprotein, meaning it spans across the cell membrane and has carbohydrate chains attached. It is predominantly expressed in the nervous system, particularly in neurons.

Functionally, Caspr3 is thought to play a role in the formation and maintenance of myelin sheaths, which insulate nerve fibers and facilitate rapid signal transmission. It interacts with other cell adhesion molecules and extracellular matrix components to establish and stabilize these crucial structures. Research suggests that Caspr3 may also be involved in neuronal signaling and the development of synaptic connections.

Mutations or dysregulation of the Caspr3 gene have been implicated in certain neurological disorders, although the exact mechanisms are still under investigation. Studies have explored its potential contribution to conditions affecting myelination and nerve function. Further research is ongoing to fully elucidate the complex roles of Caspr3 in both normal brain development and the pathophysiology of neurological diseases.