Biodistribución

Biodistribución refers to the study of how a substance, such as a drug or chemical, is distributed throughout a living organism after administration. It investigates the movement of the substance from the site of administration into various tissues, organs, and biological fluids. This process is crucial for understanding a substance's efficacy, toxicity, and potential side effects.

Key factors influencing biodistribution include the substance's physicochemical properties (like solubility and lipophilicity), the route of administration, and the physiological characteristics of the organism (such as blood flow and tissue permeability). Once in the bloodstream, a substance can bind to plasma proteins, be metabolized, or cross biological membranes to reach its target sites.

Researchers use various techniques to study biodistribution, including radiolabeling, chromatography, and imaging methods. Understanding biodistribution helps in determining appropriate dosages, predicting therapeutic outcomes, and identifying potential accumulation in specific organs that could lead to adverse effects. It is a fundamental aspect of pharmacology, toxicology, and drug development.