Aquaporin2Wasserkanälen

Aquaporin2Wass refers to a specific variant or engineered form of aquaporin-2 (AQP2), a water channel protein found in mammalian kidneys. Aquaporins are a family of integral membrane proteins that facilitate the transport of water across cell membranes. AQP2 plays a crucial role in the kidney's ability to concentrate urine, primarily in the collecting ducts. It is regulated by the hormone vasopressin (also known as antidiuretic hormone or ADH), which signals the insertion of AQP2 channels into the apical membrane of principal cells. This process increases the permeability of the collecting duct to water, allowing it to move from the filtrate back into the body and thus reducing water loss.

The "Wass" designation likely indicates a specific modification, mutation, or functional characteristic of this particular AQP2 protein. Research into such variants is often conducted to understand the precise mechanisms of water transport, the role of AQP2 in various physiological and pathological conditions, and to develop potential therapeutic strategies for diseases related to water balance, such as diabetes insipidus. Studies involving AQP2Wass might investigate changes in channel conductivity, trafficking, or regulation compared to the wild-type protein. Understanding these variations can provide insights into the delicate balance of fluid homeostasis maintained by the kidney.