Antigeneling

Antigeneling is a term that describes the process by which an organism's immune system becomes less responsive to a specific antigen. This can occur through several mechanisms. One common way is through repeated exposure to the antigen, which can lead to a state of tolerance. This is often observed in cases of chronic infections or autoimmune diseases, where the immune system fails to mount an effective response against the body's own tissues or persistent pathogens.

Another aspect of antigeneling involves regulatory immune cells, such as regulatory T cells (Tregs). These cells actively suppress the immune response, preventing excessive inflammation and autoimmunity. When Tregs become more numerous or more active in the presence of a particular antigen, they can lead to antigeneling. Factors like the dose and route of antigen administration, as well as the presence of other immune signals, can influence the development of antigeneling. Understanding antigeneling is crucial in fields like immunology and transplantation, as it can impact the success of treatments and therapies aimed at modulating immune responses.