ARHGAP11

ARHGAP11, also known as Rho GTPase activating protein 11, is a protein encoded by the ARHGAP11 gene. It plays a crucial role in regulating cell shape, motility, and division by acting as a GTPase-activating protein (GAP) for Rho GTPases. Specifically, ARHGAP11 catalyzes the hydrolysis of GTP to GDP on Rho proteins, thereby switching them to their inactive state. This precise control over Rho GTPase activity is essential for various cellular processes.

ARHGAP11 has been implicated in a number of biological functions. Its involvement in cytoskeletal organization influences cell morphology and the formation of structures like filopodia and lamellipodia, which are critical for cell movement. Furthermore, ARHGAP11 has been linked to the regulation of cell proliferation and differentiation. Studies suggest it can impact cell cycle progression and contribute to the development of specific cell types. Research into ARHGAP11 has also explored its potential role in disease, particularly in the context of cancer, where dysregulation of cell growth and motility is a hallmark. Understanding the precise mechanisms by which ARHGAP11 functions continues to be an active area of scientific investigation.