AMPKähnliche

AMPKähnliche (AMP-activated protein kinase-like) are a group of enzymes that share structural and functional similarities with AMP-activated protein kinase (AMPK). AMPK is a key regulator of cellular energy homeostasis, and AMPKähnliche proteins play similar roles in various organisms, including plants, fungi, and some bacteria. These enzymes are activated by increases in the AMP:ATP ratio, which occurs during periods of low energy availability. Activation of AMPKähnliche proteins leads to the regulation of metabolic processes, such as glucose uptake, fatty acid oxidation, and protein synthesis, to restore energy balance. The discovery of AMPKähnliche proteins has provided valuable insights into the evolutionary conservation of energy regulation mechanisms across different kingdoms of life.