ABHD6

ABHD6, also known as abhydrolase domain containing 6, is a protein-coding gene. This gene encodes a serine hydrolase enzyme that is involved in lipid metabolism. It is a member of the alpha/beta-hydrolase superfamily. The protein is primarily expressed in the brain and plays a role in regulating neurotransmitter levels and synaptic plasticity.

Research suggests that ABHD6 is involved in the hydrolysis of N-acylphosphatidylethanolamines (NAPEs), which are precursors to endocannabinoids. By hydrolyzing NAPEs, ABHD6 influences the levels of endocannabinoids in the body. Endocannabinoids are lipid-based signaling molecules that play a crucial role in various physiological processes, including appetite, pain sensation, mood, and memory.

Dysregulation of ABHD6 has been implicated in neurological disorders. Studies have explored its potential involvement in conditions such as addiction, depression, and anxiety. Inhibiting ABHD6 activity has been investigated as a potential therapeutic strategy for these conditions by modulating endocannabinoid signaling. Further research is ongoing to fully elucidate the complex roles of ABHD6 in human health and disease.