3Picoline

3-Picoline, also known as m-picoline, is an aromatic heterocyclic amine and one of the three methylpyridine isomers. It consists of a pyridine ring bearing a methyl group at the 3-position. Like other picolines, it is a volatile, colorless liquid with a pyridine-like odor. It is slightly soluble in water and miscible with many organic solvents. The compound is flammable and should be handled in well-ventilated areas away from heat sources.

Production and sources: Industrially, 3-picoline is produced by methylation of pyridine using methanol or other methylating agents, with subsequent purification to isolate the 3-isomer. It can also arise as a byproduct in the manufacture of other methylpyridines and related coal tar or petroleum fractions.

Uses: 3-Picoline is primarily used as a chemical intermediate. It serves as a building block in the synthesis of agrochemicals and pharmaceuticals, as well as in the preparation of various pyridine derivatives used in research and industry. It can be converted into other nicotinyl and pyridyl compounds.

Safety and handling: It is toxic and may be hazardous if inhaled, ingested, or absorbed through the skin. It can irritate the skin, eyes, and respiratory tract. Handling should occur with appropriate personal protective equipment, good ventilation, and standard containment practices. Spills should be cleaned up with inert absorbents, and releases to the environment should be avoided.

See also: 2-picoline, 4-picoline.