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13bisphosphoglycerate

1,3-bisphosphoglycerate, commonly abbreviated as 1,3-BPG or 13-BPG, is a phosphorylated intermediate in glycolysis. It is formed from glyceraldehyde-3-phosphate by the enzyme glyceraldehyde-3-phosphate dehydrogenase in a redox reaction that reduces NAD+ to NADH and incorporates an inorganic phosphate to yield a high-energy acyl phosphate on carbon 1 while preserving a phosphate on carbon 3.

Chemically, it contains phosphate esters at both the C1 and C3 positions of the glycerol backbone. The

The next step in glycolysis is catalyzed by phosphoglycerate kinase, which transfers the high-energy phosphate from

In addition to its central role in energy metabolism, 1,3-BPG links redox chemistry to energy capture. Cellular

1,3-BPG is typically present only transiently in the cytosol during active glycolysis. See also glycolysis, glyceraldehyde-3-phosphate

formation
of
the
molecule
couples
oxidation
of
glyceraldehyde-3-phosphate
to
the
generation
of
a
high-energy
phosphate
bond
that
can
be
exploited
for
ATP
production.
C1
to
ADP,
producing
ATP
and
3-phosphoglycerate.
This
reaction
provides
one
molecule
of
substrate-level
ATP
per
molecule
of
1,3-BPG
formed,
contributing
to
the
overall
energy
yield
of
glycolysis.
concentrations
of
1,3-BPG
reflect
glycolytic
flux,
and
in
erythrocytes
a
related
shunt
converts
1,3-BPG
to
2,3-bisphosphoglycerate
(2,3-BPG),
a
regulator
of
hemoglobin's
oxygen
affinity.
dehydrogenase,
phosphoglycerate
kinase,
and
2,3-bisphosphoglycerate.