125dihidroxivitamin

125-dihidroxivitamin is a term that refers to a specific dihydroxylated form of vitamin D. Vitamin D is a fat-soluble vitamin that plays a crucial role in calcium absorption, bone health, and immune function. It exists in several forms, and its biological activity is mediated by its hydroxylated metabolites. The dihydroxylation process typically occurs in two stages, first in the liver and then in the kidneys, to produce the biologically active form of vitamin D, which is calcitriol (1,25-dihydroxyvitamin D). The designation "125-dihidroxivitamin" specifically indicates hydroxylation at the 1 and 25 positions of the vitamin D molecule. This metabolite is the primary hormone that regulates calcium and phosphate homeostasis in the body. Its synthesis is tightly controlled by parathyroid hormone and serum phosphate levels. Deficiency in vitamin D or impaired ability to metabolize it can lead to various health issues, including rickets in children and osteomalacia in adults. Research into different dihydroxylated forms of vitamin D is ongoing, exploring potential therapeutic applications beyond its established roles in bone metabolism.