tiamiinipürofosfaat
Tiamiinipürofosfaat, also known as thiamine pyrophosphate (TPP), is the biologically active coenzyme form of thiamine (vitamin B1). It plays a crucial role in carbohydrate metabolism, acting as a cofactor for several key enzymes involved in energy production. Specifically, TPP is essential for the function of enzymes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase.
These enzymes are involved in vital metabolic pathways, including glycolysis, the citric acid cycle, and the
The deficiency of thiamine, and consequently TPP, leads to a condition known as beriberi. Beriberi can manifest