taxadiene
Taxadiene (taxa-4(5),11(12)-diene) is a bicyclic diterpene hydrocarbon that serves as the first dedicated intermediate in the biosynthesis of paclitaxel (taxol). The molecule contains 20 carbon atoms arranged in a fused bicyclic skeleton and bears two nonconjugated double bonds, as indicated by its name.
Natural occurrence and biosynthesis: Taxadiene is produced in Taxus species (yews) from geranylgeranyl pyrophosphate (GGPP) through
Applications and significance: Taxadiene is the first dedicated precursor in paclitaxel biosynthesis and remains a focal