proteasometargeting
Proteasome targeting refers to strategies that modulate the proteasome–a central component of the ubiquitin–proteasome system that degrades most intracellular proteins–to influence protein turnover. The term encompasses proteasome inhibitors, proteasome activators, and approaches that direct proteins to degradation via ubiquitination and the proteasome, such as proteolysis-targeting chimeras (PROTACs) and related molecular glues.
The 26S proteasome consists of a 20S core particle providing proteolytic activities and a 19S regulatory particle
Proteasome activators and modulators aim to enhance proteasomal degradation, a concept under study for diseases characterized
Proteolysis-targeting strategies recruit E3 ubiquitin ligases to a target protein, tagging it with ubiquitin and routing
Challenges include achieving selectivity, avoiding unintended degradation of proteins, and managing resistance and toxicity. Proteasome-targeting remains