polyadenyloinnissa

Polyadenylation is a post-transcriptional modification process that occurs in the nucleus of eukaryotic cells. It involves the addition of a poly(A) tail to the 3' end of messenger RNA (mRNA) molecules. This process is crucial for the stability and translation of mRNA. The poly(A) tail is synthesized by the enzyme poly(A) polymerase, which uses ATP as a substrate. The length of the poly(A) tail can vary, typically ranging from 100 to 250 adenine nucleotides, and it plays a role in mRNA stability, transport, and degradation. Polyadenylation is a highly conserved process across eukaryotic organisms and is essential for proper gene expression. Mutations or defects in polyadenylation can lead to various diseases, including cancer and neurodegenerative disorders. The poly(A) tail is also a target for certain therapeutic strategies, such as antisense oligonucleotides, which can modulate gene expression by interfering with polyadenylation.