platinaaddukteihin

Platinaaddukteihin, known in English as platinum adducts, are chemical compounds formed when platinum atoms or platinum-containing molecules bind to other molecules, typically biological ones. These adducts play a significant role in the mechanism of action of certain platinum-based chemotherapy drugs. When these drugs are administered, they can react with DNA, forming covalent bonds with the nitrogen atoms in the guanine bases. These platinum-DNA adducts can distort the DNA structure, interfering with DNA replication and transcription, ultimately leading to cell death, particularly in rapidly dividing cancer cells.

The formation and repair of platinum adducts are crucial aspects of platinum chemotherapy efficacy and resistance. Cells have sophisticated DNA repair mechanisms that can recognize and remove these adducts. However, if the damage is too extensive or the repair mechanisms are overwhelmed or defective, the cell cycle arrest and apoptosis pathways are triggered. The specific type and location of platinum adducts formed can influence the cellular response. Different platinum drugs, such as cisplatin, carboplatin, and oxaliplatin, form various adducts, and their reactivity and the body's ability to process them contribute to their therapeutic profiles and side effects. Research into platinum adducts continues to explore ways to enhance their formation in cancer cells, improve DNA repair inhibition, and overcome drug resistance.