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Organophosphate poisoning, also known as organophosphate intoxication, is a condition caused by the ingestion, inhalation, or absorption of organophosphate compounds. These compounds are widely used in agriculture as pesticides, in industry for flame retardants, and in medicine for insecticides and nerve agents. Organophosphates inhibit the enzyme acetylcholinesterase, which is crucial for breaking down the neurotransmitter acetylcholine. This inhibition leads to an accumulation of acetylcholine in the synapses, resulting in excessive stimulation of cholinergic receptors. The symptoms of organophosphate poisoning can vary depending on the route of exposure and the specific organophosphate involved. Common symptoms include muscle weakness, nausea, vomiting, diarrhea, abdominal pain, and in severe cases, respiratory failure and seizures. Diagnosis is typically based on clinical symptoms and confirmed by measuring the level of organophosphate compounds in the blood or urine. Treatment focuses on supportive care, including the administration of atropine to counteract the effects of acetylcholine, and in severe cases, the use of pralidoxime to reactivate inhibited acetylcholinesterase. Prevention involves avoiding exposure to organophosphate compounds, using appropriate personal protective equipment, and following safe handling and disposal procedures.