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Oxaloacetate is a four-carbon dicarboxylic acid that plays a crucial role in metabolism. It is an intermediate in the citric acid cycle, also known as the Krebs cycle or TCA cycle, a central pathway for the generation of energy in aerobic organisms. In this cycle, oxaloacetate is condensed with acetyl-CoA to form citrate, and it is regenerated at the end of the cycle, allowing the process to continue.
Beyond its role in the citric acid cycle, oxaloacetate is involved in gluconeogenesis, the process by which
The concentration of oxaloacetate within cells is tightly regulated to ensure proper metabolic flow. Its production