nonribosomallike

Nonribosomal peptide synthetases (NRPSs) are a class of enzymes that catalyze the synthesis of nonribosomal peptides, which are a diverse group of secondary metabolites found in bacteria, fungi, and plants. NRPSs are distinct from ribosomal peptide synthetases, which are responsible for the synthesis of ribosomal peptides. NRPSs are modular enzymes, each consisting of multiple domains that are responsible for the incorporation of specific amino acids into the growing peptide chain. The modular nature of NRPSs allows for the synthesis of a wide variety of peptides with different structures and functions. NRPSs are involved in the biosynthesis of many important antibiotics, such as vancomycin and teicoplanin, as well as other bioactive peptides. The study of NRPSs and their products has led to the development of new therapeutic agents and has provided insights into the mechanisms of peptide biosynthesis.