nitazoksanidi

Nitazoxanide is a broad-spectrum antiparasitic and antiviral medication. It is primarily used to treat infections caused by protozoa and helminths. In the United States, it is approved for the treatment of diarrhea caused by the protozoa Cryptosporidium parvum and Giardia lamblia in individuals one year of age and older. It is also used off-label for a variety of other parasitic infections.

The mechanism of action of nitazoxanide is believed to involve the inhibition of the pyruvate:ferredoxin/flavodoxin oxidoreductase (PFOR) enzyme pathway, which is essential for anaerobic energy metabolism in many protozoa and anaerobic bacteria. This disruption leads to the impairment of essential metabolic functions and ultimately cell death.

Nitazoxanide is available in oral formulations, including tablets and oral suspension. Common side effects can include abdominal pain, diarrhea, nausea, vomiting, and headache. It is generally well-tolerated. Dosage and duration of treatment depend on the specific infection being treated and the age and weight of the patient. It is important to consult a healthcare professional for diagnosis and appropriate treatment. Research is also ongoing into its potential antiviral properties against a range of viruses.