netrin1receptor

Netrin-1 receptor, also known as DCC (Deleted in Colorectal Carcinoma), is a transmembrane protein belonging to the immunoglobulin superfamily. It functions as a receptor for netrin-1, a secreted protein that plays a crucial role in axon guidance during nervous system development. Netrin-1 binding to DCC triggers intracellular signaling pathways that can either attract or repel axons, depending on the cellular context. This guidance mechanism is essential for the correct formation of neuronal circuits. Beyond its role in the nervous system, DCC has also been implicated in other cellular processes, including cell adhesion, migration, and apoptosis. Its expression is found in various tissues, not just neural cells. Loss of DCC function has been linked to developmental abnormalities and certain diseases, including colorectal cancer, from which its alternative name is derived. Research continues to explore the multifaceted roles of netrin-1 receptor in both normal physiological processes and pathological conditions.