malonyylCoAn
Malonyl-CoA is the coenzyme A thioester of malonic acid and a key metabolite in lipid metabolism. It serves as a two-carbon donor unit in de novo fatty acid synthesis and also participates in polyketide biosynthesis in certain organisms. In mammals, it plays a regulatory role by linking energy status to fatty acid oxidation.
Malonyl-CoA is produced by acetyl-CoA carboxylase (ACC) through an ATP- and biotin-dependent carboxylation of acetyl-CoA with
Metabolic roles include its function as the initial substrate for fatty acid synthase during lipogenesis. Additionally,
Beyond metabolism, malonyl-CoA serves as a donor substrate for protein lysine malonylation, a post-translational modification that