inotrooppisiin

Inotrooppiset refers to a category of drugs that alter the contractility of the heart muscle. These substances are broadly classified as positive inotropes, which increase the force of myocardial contraction, and negative inotropes, which decrease it. Positive inotropic agents are crucial in managing conditions such as heart failure and certain types of shock, where the heart's pumping ability is compromised. By enhancing contractility, they improve cardiac output and tissue perfusion. Examples of positive inotropes include digitalis glycosides like digoxin, phosphodiesterase inhibitors like milrinone, and catecholamines such as dopamine and dobutamine.

Conversely, negative inotropic drugs are used to reduce the workload on the heart, particularly in conditions like hypertrophic cardiomyopathy or when managing certain arrhythmias. By decreasing contractility, they can lower oxygen demand and reduce the risk of symptoms related to excessive cardiac strain. Beta-blockers and some calcium channel blockers can exhibit negative inotropic effects. The use of inotropic agents requires careful medical supervision due to their potent effects and potential for adverse reactions, including arrhythmias and significant changes in blood pressure. The specific choice of inotropic agent and its dosage depend on the patient's underlying condition, clinical status, and response to treatment.