inositol145trisphosphate
Inositol-1,4,5-trisphosphate, often abbreviated as IP3, is a naturally occurring molecule within cells. It is a key second messenger in intracellular signal transduction. IP3 is derived from the lipid phosphatidylinositol 4,5-bisphosphate (PIP2), which is found in the cell's plasma membrane. When certain cell surface receptors are activated, an enzyme called phospholipase C cleaves PIP2 into two molecules: diacylglycerol (DAG) and IP3.
The primary role of IP3 is to trigger the release of calcium ions (Ca2+) from intracellular stores,
The concentration of IP3 within the cell is tightly regulated. Enzymes like inositol polyphosphate 5-phosphatase rapidly