hüdroaminatsioon

Hydroamination is a chemical reaction where an amine, containing an N-H bond, adds across a carbon-carbon double or triple bond. This process results in the formation of a new carbon-nitrogen bond and a carbon-hydrogen bond, effectively attaching the amine to the unsaturated hydrocarbon. The reaction is typically catalyzed by transition metals, although some organocatalytic systems have also been developed. Common catalysts include complexes of palladium, platinum, rhodium, iridium, and rare earth metals. The regioselectivity of the addition, meaning where the amine group attaches to the carbon chain, can be controlled by the choice of catalyst and reaction conditions. This can lead to either Markovnikov addition (amine adds to the more substituted carbon) or anti-Markovnikov addition (amine adds to the less substituted carbon). Hydroamination is a valuable synthetic tool in organic chemistry as it provides a direct route to amines, which are important functional groups found in pharmaceuticals, agrochemicals, and polymers. It offers an atom-economical method for C-N bond formation, as it avoids the generation of byproducts.