histonene
Histones are small, highly basic nuclear proteins that package and organize DNA in eukaryotic cells. The core histones—H2A, H2B, H3, and H4—assemble into a histone octamer around which about 147 base pairs of DNA are wrapped to form a nucleosome, the fundamental unit of chromatin. Two copies of each core histone constitute the octamer. The linker histone H1 binds to the DNA between nucleosomes and helps compact chromatin into higher-order fibers.
Variants of histones exist. In addition to canonical histones, cells express replacement variants such as H3.3,
Histone tails protruding from the nucleosome are subject to a range of post-translational modifications, including acetylation,
Histones are deposited onto DNA by histone chaperones and remodeled during transcription and replication. Complexes such