glycerol3phosphateresponsive
Glycerol3phosphate, also known as alpha-glycerophosphate or sn-glycerol-3-phosphate, is a phosphorylated form of glycerol. It is a crucial molecule in biological systems, playing a central role in lipid metabolism and energy production. In eukaryotic cells, glycerol-3-phosphate is primarily synthesized from glycerol or dihydroxyacetone phosphate. The enzyme glycerol-3-phosphate dehydrogenase catalyzes the reduction of dihydroxyacetone phosphate to glycerol-3-phosphate, a key step in glycolysis. Alternatively, glycerol kinase can phosphorylate glycerol to glycerol-3-phosphate.
Glycerol-3-phosphate serves as the backbone for the synthesis of phospholipids and triglycerides, the main components of