glukuronidace

Glucuronidation, also known as glucuronidace, is a phase II metabolic process that involves the conjugation of glucuronic acid to various endogenous and exogenous compounds. This process is primarily catalyzed by glucuronosyltransferases, a family of enzymes that transfer glucuronic acid from UDP-glucuronic acid to the substrate. Glucuronidation is a common detoxification pathway in the liver and plays a crucial role in the elimination of drugs, hormones, and other endogenous substances from the body. The glucuronidated conjugates are typically more water-soluble than the parent compounds, facilitating their excretion via the kidneys or bile. This process is essential for maintaining homeostasis and preventing the accumulation of potentially harmful substances. Glucuronidation can also influence the pharmacokinetics and pharmacodynamics of drugs, affecting their absorption, distribution, metabolism, and excretion. The efficiency of glucuronidation can vary among individuals, leading to differences in drug response and potential drug interactions.