fibrinmonomerré

Fibrinogen is a soluble protein found in blood plasma. It is synthesized in the liver and plays a crucial role in hemostasis, the process of stopping bleeding. Fibrinogen circulates in the blood in an inactive form.

When a blood vessel is injured, a cascade of reactions is initiated, leading to the activation of thrombin. Thrombin is an enzyme that specifically cleaves fibrinogen into smaller molecules called fibrin monomers. These fibrin monomers then spontaneously polymerize, forming long, insoluble strands of fibrin. These fibrin strands assemble into a mesh-like network that traps blood cells and platelets, forming a blood clot. This clot effectively seals the damaged blood vessel, preventing further blood loss.

The process of converting fibrinogen to fibrin is essential for wound healing and preventing hemorrhage. Disorders affecting fibrinogen levels or function can lead to abnormal bleeding or an increased tendency to form blood clots. Fibrinogen itself is a large, complex molecule composed of three pairs of polypeptide chains. Its precise structure and the enzymatic cleavage by thrombin are key to the formation of a stable fibrin clot.