desferrioxamines
Desferrioxamines are a family of siderophores produced by various actinomycetes, notably Streptomyces species, that function to scavenge ferric iron (Fe3+) from the environment. They play a key role in microbial iron acquisition under iron-limited conditions by binding Fe3+ and delivering it to bacterial uptake systems. The most studied member is desferrioxamine B, also known clinically as deferoxamine.
Chemistry and coordination chemistry: Desferrioxamine B is a linear molecule bearing three N-hydroxyamide groups that coordinate
Biosynthesis and biology: In Streptomyces and related bacteria, desferrioxamines are produced via nonribosomal peptide synthetase pathways,
Clinical and research relevance: Desferrioxamine B is used clinically as an iron chelator to treat iron overload