deltagranuloistaan
Deltagranuloistaan is the Finnish term for the dense granules of platelets, the small, electron-dense secretory organelles that play a key role in hemostasis. Dense granules, also known as delta granules, differ from the larger alpha granules in contents and function. The principal constituents stored in dense granules are adenosine diphosphate (ADP), adenosine triphosphate (ATP), calcium ions and serotonin. These molecules are released when platelets are activated at sites of vascular injury, enhancing platelet recruitment and amplification of the hemostatic response.
Functionally, the released ADP and ATP promote further platelet activation and aggregation, while calcium supports the
Clinical relevance: Abnormalities of delta granules can cause bleeding disorders. Storage pool diseases involve reduced dense
Diagnosis typically relies on platelet electron microscopy to quantify dense bodies; functional testing (platelet aggregation studies)