Vph1

Vph1 is a protein found in yeast, specifically in the vacuolar H+-ATPase (V-ATPase) complex. This complex is a vital proton pump responsible for acidifying intracellular organelles, including the vacuole. The V-ATPase is a large, multi-subunit enzyme that plays a crucial role in various cellular processes such as protein degradation, storage, and ion homeostasis. Vph1 is a component of the V0 domain of the V-ATPase, which is embedded in the membrane and facilitates proton translocation. The gene encoding Vph1 is essential for the proper assembly and function of the V-ATPase in yeast. Mutations or disruptions in Vph1 can lead to impaired vacuolar acidification, resulting in a range of cellular defects. Research on Vph1 has contributed to a broader understanding of V-ATPase structure, function, and its implications in cellular biology. Its study helps elucidate the mechanisms by which proton pumps contribute to maintaining cellular environments.