VDj
VDJ refers to the somatic recombination of variable (V), diversity (D), and joining (J) gene segments that generates the diverse antigen receptor genes of B and T lymphocytes. This mechanism creates the variable regions of immunoglobulin chains in B cells and T-cell receptor chains in T cells, enabling recognition of a wide array of antigens.
In B cells, the heavy chain locus rearranges V, D, and J segments to form a functional
The rearrangement is initiated by the RAG1 and RAG2 recombinases, which cut DNA at recombination signal sequences
VDJ recombination occurs during lymphocyte development in primary lymphoid organs (bone marrow for B cells and
Defects in VDJ recombination or RAG genes can cause immunodeficiencies such as severe combined immunodeficiency and