TET3

TET3, also known as TET family member 3, is a protein-coding gene. It belongs to the Ten-Eleven Translocation (TET) family of dioxygenase enzymes. These enzymes play a critical role in DNA demethylation, a process that involves the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidized derivatives. This active demethylation pathway is crucial for regulating gene expression and maintaining genomic stability.

TET3 is expressed in various tissues and plays a significant role during embryonic development. It is particularly important for the reprogramming of DNA methylation patterns that occurs during gametogenesis and early embryogenesis. The enzymatic activity of TET3 is dependent on iron and alpha-ketoglutarate as cofactors. Aberrant TET3 function has been implicated in various diseases, including certain types of cancer and developmental disorders, highlighting its importance in cellular processes. Research into TET3 continues to explore its precise roles in epigenetic regulation and its potential as a therapeutic target.