SufBcontaining

SufBcontaining is a term that refers to proteins which contain the SufB domain. The SufB domain is a conserved protein domain found in various organisms, particularly in bacteria and archaea. This domain is a key component of the SufB-SufC-SufA operon, which is involved in the biosynthesis of iron-sulfur clusters. Iron-sulfur clusters are essential inorganic cofactors that play crucial roles in numerous biological processes, including electron transfer, DNA repair, and enzyme catalysis.

Proteins containing the SufB domain are typically involved in sulfur metabolism and iron homeostasis. The SufB protein itself is thought to be a sulfurtransferase, catalyzing the transfer of sulfur atoms from a donor molecule to an acceptor, ultimately contributing to the assembly of iron-sulfur clusters. The interaction between SufB, SufC, and SufA forms a complex that facilitates the mobilization and delivery of sulfur for these clusters. Understanding the structure and function of SufBcontaining proteins is vital for comprehending the intricate mechanisms of iron-sulfur cluster biogenesis and its impact on cellular health and function. Disruptions in this pathway can lead to various cellular defects and diseases.